ObjectiveTo compare the clinical efficacy of natural orifice specimen extraction surgery (NOSES) and traditional laparoscopic operation in the treatment of colorectal cancer. MethodsThirty-nine colorectal cancer patients treated with NOSES were selected as an observation group, and another 39 colorectal cancer patients who were treated with laparoscopic surgery during the same period and whose general data were balanced and comparable to those of the observation group were selected as a control group. The operation related indicators, postoperative recovery indicators, pain indicators, and the occurrence of complications were compared between the two groups. ResultsThe observation group had longer operation time than that of the control group, with a statistically significant difference (P＜0.05).There were no statistically significant differences in intraoperative blood volume, number of lymph nodes dissection, drainage tube indwelling time, first postoperative feeding time, postoperative analgesic pump use time, and postoperative hospital stay between the two groups (all P＞0.05). The first exhaust time, first defecation time and first ambulation time in the observation group were shorter than those in the control group, with statistically significant differences (all P＜0.05). The VAS score 24 hours after operation of observation group was lower than that of the control group, with a statistically significant difference (P＜0.05). The incidence of complications in the observation group was 7.69%, which was significantly lower than 28.21% in the control group, with a statistically significant difference (P＜0.05). ConclusionCompared with traditional laparoscopic operation, the operation time of NOSES for colorectal cancer is prolonged, but NOSES can promote the postoperative recovery of patients, relieve postoperative pain, and reduce postoperative complications.

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