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目的探讨造血干细胞移植后早期感染的临床特点。方法对36例2001年1月至2010年7月接受造血干细胞移植患者的临床资料进行分析。结果共有31例（86.1%）患者在移植后出现感染。移植早期感染种类以细菌为主,其中革兰氏阴性菌71.4%,阳性菌23.8%。感染部位以呼吸道感染为首位,占54.1%,其次是口腔黏膜、胃肠道、皮肤等,未发现感染病灶者3例。合并急性移植物抗宿主病者感染的发生率与未合并者比较差异无统计学意义。结论造血干细胞移植早期感染的发生率非常高,以革兰氏阴性菌为主,合理使用抗菌药物、预防真菌感染等是防治造血干细胞移植患者早期感染的重要措施。
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造血干细胞移植后早期感染的临床研究
Clinical investigation on early infections after hematopoietic stem cell transplantation
微创医学 201103期 页码：193-196
作者机构：[1]昆明医学院第一附属医院血液科,昆明市650032; [2]昆明医学院微生物免疫教研室,昆明市650031
基金信息：收稿日期: 2011-02-18
- 中文简介
- 英文简介
- 参考文献
Objective To investigate the clinical characters of early infections after hematopoietic stem cell transplantation（HSCT）.Methods The clinical data of 36 cases of early infections after hematopoietic stem cell transplantation from Jan 2001 to Jul 2006 were analyzed.Results Infection after transplantation occurred in 31 patients（86.1%）.The main pathogens of the early stage were microbes,among which 23.8% were Gram positive and 71.4% were Gram negative.Infection occurred mainly in respiratory tract（54.1%）,followed by oral cavity,intestinal tract and skin.No infection focus was found in 3 cases.There existed no significant difference in infection incidence rate between patients complicated with acute graft versus host disease and without.Conclusions There is a high infection incidence rate for patients in early stage after HSCT.The pathogens are mainly Gram-negative bacteria.A reasonable use of antibiotics and preventing the fungal infection are good ways to control early infections after HSCT.
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