目的探讨内镜下氩离子凝固术(APC)联合埃索美拉唑治疗对Barrett食管(BE)的临床疗效。方法选择经内镜及病理证实的52例BE患者,在内镜下行APC治疗,再给予埃索美拉唑抑酸40 mg/d口服8周。术后进行内镜、病理随访12个月。结果 52例均完成治疗,其中需要1次治疗者40例,2次者10例,3次者2例。49例达到完全的鳞状上皮再生(94.2%),3例再生的鳞状上皮间混有岛状的柱状上皮(5.8%)。12个月后共有6例出现内镜下可见的复发。结论内镜下APC联合埃索美拉唑治疗BE简单、安全、有效,但有一定比例的残留和复发
Objective To explore the clinical effect of the argon plasma coagulation(APC) under endoscope combined with esomeprazole on Barrett′s esophagus(BE).Methods Fifty-two patients with Barrett′S esophagus confirmed by endoscope and pathology method were treated with APC and successive acid suppression therapy by esomeprazole for 8 weeks.All the patients were rechecked by endoscope and pathology method on 1,6 and 12 month after treatment.Results The follow-up was accomplished in all patients.The eradication was obtained in 40 cases by only one session and 10 cases by two sessions,2 cases by three sessions.The complete squamous reepithelialization was observed in 49 patients(94.2%),whereas remnant islands of columnar epithelium mixed with squamous reepithelialization in the original places were observed in 3 patients(5.8%).The reappearance of columnar epithelium was observed in 6 patients during follow-up.Conclusion The APC therapy combined with esomeprazole is effective and safe in the reversal of BE.However,recurrences and residual of BE occur in certain patients.