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目的研究垂体腺瘤中垂体瘤转化基因（PTTG）、血管内皮生长因子（VEGF）的表达水平,及其恶性侵袭程度的相关性。方法选用50例垂体腺瘤标本,根据影像学表现分为局限性垂体腺瘤（n=22）和侵袭性垂体腺瘤（n=28）,采用免疫组化染色方法测定标本中PTTG、VEGF的表达水平,并进行两者的相关性分析。结果侵袭组垂体腺瘤标本中PTTG、VEGF表达水平比局限组显著增高（P〈0.05）。在侵袭组垂体瘤中,PTTG的表达和VEGF的表达呈正相关（r=0.762,P〈0.01）,提示两指标的高表达与垂体腺瘤的侵袭性呈正相关。结论垂体腺瘤中PTTG、VEGF表达水平与其侵袭性密切相关,可作为预测垂体腺瘤侵袭性的良好指标
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垂体腺瘤中PTTG、VEGF表达水平与其恶性侵袭程度的相关分析
Correlation analysis between the expressions of PTTG and VEGF and the malignant invasive grade in pituitary adenomas
微创医学 201102期 页码：94-96
作者机构： 广西医科大学第一附属医院,南宁市530021
基金信息： 收稿日期：2011-01-20
- 中文简介
- 英文简介
- 参考文献
Objective To explore the express levels of pituitary tumor transforming gene（PTTG） and vascular endothelial growth factor（VEGF） and their correlations with the malignant invasive degree in pituitary adenoma.Methods The protein expressions of PTTG and VEGF in pituitary adenomas specimen of 50 patients（28 cases in invasive group,22 cases in non-invasive group,grouped by their imageology performance） were assayed by immunohistochemical staining technique,and its correlation analysis with the malignance grade were carried out.Results The protein expression of PTTG and VEGF in the invasive pituitary adenomas were higher than those in the non-invasive group（P0.05）.A correlation analysis showed that there was a negative correlation between PTTG and VEGF in invasive pituitary adenomas（r=0.762,P0.0 1）.Conclusion PTTG and VEGF may be correlated with the invasiveness of pituitary adenoma,indicating they can be acting as valuable biological predicting markers.
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