Objective  To investigate the significance of rat liver HSP70 in the evaluation of surg ical trauma degree. Methods  To estab lish surgical trauma models of rats with different hepatectomy. A total of 160 healthy male SD rats were d ivided in to four groups random ly: normal con trols, mild, moderate and severe hepatic trauma group. The exp ression ofHSP70 in hepatic tissuewas dynam ically detected byWestern blotting at 2, 8, 12, 24, and 48 h after in jury. Results  The express ion ofHSP70 in trauma groups increased rap id ly, peaked at 8h, then gradually declined, and reduced to normal level at 48 h. W ith the increase of liver resection rate, the express ion increase tendency ofHPS 70was more eviden.t Conclusion  The expression of HSP70 in liver tissue augments after surgical trau a, peaks at 8h, suggesting thatHSP70 may participate in in itiating anti-injury mechanism of hepatic cells. W ith the increase in the amount of liver cut the expression ofHSP 70 increases, suggesting the express ion ofHSP 70 can be used as an indicator to diagnose the degree of hepatic surgical trauma.

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