Objective To explore the effect of multi-time blood glucose monitoring on diabetic cardiovascular disease． Method 76 diagnosed type 2 diabetic patients of the multi-time control group were underwent multi-time glucose monitoring every month and adjusted hypoglycemic drug to stable blod glucose， while 35 patients of the control group were adjusted their hypoglycemic drug according only to fasting and postprandial blood glucose． All patients were regularily measured with blood glucose，blood pressure，HbAl1， ECG，cardiac B ultrasound，and DCG． TNF-a and IGF-1 of the two groups before and after study were measured as well． Result The rates of improvement and stability of diabetic cardiovascular disease in multi-time group were higher than those in control group，and their level of TNF-α and IGF-1 were lower than those in control group． Conclusion Multi-time blood glucose control can defer the onset of and development of complication of diabetic cardiovascular disease in type 2 diabetes，improve cardiovascular disease，and decrease the expression of TNF-α and IGF-1．

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